The practical reality is the we need Some regulations.
But the practical reality is that government regulation metastasizes.
IIRC there are now more people working for the farm bureau than there are farmers, the department of energy's sole mandate was to alleviate US dependency on foreign oil I has not reduced the US dependency on foreign oil one iota. Yet it employees 93,000 on contract and another 12,000 on payroll. With a budget of 28 billion dollars, In Calif we now have cap and trade to regulate pollutants, on top of the EPA and the AQMD, those are off the top of my head.
To just create more regulations is NOT the answer.
The best protector of these sorts of things is private property and the legal system. If truck drivers create problems then the best solution is a law suit. This causes the truck drivers liability insurance to go up. And the truck driver can no longer work.
The legal system too is subject to government influences therefore that too is best left to the private sector. Then if judges are found to be unfair people would avoid using them in an arbitration.
BTW improved technology also solves these problems as with fracking and the foreign oil situation. Self driving trucks could be the solution to the problem you bring up.