There are several things to look at before making the move to nesting.
What is your current process? Why do you think nesting is a better alternative.
What is the nature of the parts you are machining? Are the parts rectangles with limited drilling or complex shapes with multiple tool changes required for machining. This will give a better idea of the cycle time and machine requirements.
160-210 - sheets per day over 2 shifts. This amounts to 1 sheet every 6 to 4.5 minutes. Depending on the patterns you are cutting this may or may not be possible. Salesman often overlook the human factor when sheets per day is discussed. Also salesman like to talk about cutting speeds and positioning speeds, but seldom talk about boring speeds and the amount of time to process. It has been my experience that boring often takes as much or more time as routing takes in a pattern.
Type of machine. Moving Gantry or Moving Table. The machines you noted, it looks like Komo is a moving table and the Weeke is a moving gantry. The different types of machines can have substantial different costs. Also the quality of components and expected life span of the machine.
Material Handing or not. Material handling is a nice option and will shorten your sheet to sheet time, and get you more through put in a day. The option is not cheap but neither is hourly wage labor. In the end material handling should pay for itself.
Horizontal Boring. As previously mentioned, horizontal boring is not a good option for any flat table machine. A dedicated horizontal boring machine will be much, much, much more efficient.
In the end, investigate your different options, there are several out there.
Control. What type of control does the machine have, Is Komo still using a Fanuc control? If so this I like that the this is an industrial control and quite popular, meaning parts and service are fairly easy to come by. What type of control does the Weeke have.
In the shop I work for we have a Komo w/ material handling which was purchased in 2008, when machines were still manufactured in Minnesota. It is a good machine and we have had very few issues with that machine.
Good luck.